NCIt definition : A monoclonal antibody directed against the cell surface receptor CD39 (cluster of
differentiation 39; ectonucleoside triphosphate diphosphohydrolase-1; NTPDase1; ENTPD1),
with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CD39 monoclonal antibody IPH5201 specifically targets and binds to the CD39 antigen,
thereby preventing the conversion and degradation of the immune-stimulatory adenosine
triphosphate (ATP) to adenosine monophosphate (AMP). This leads to an increase in
the extracellular levels of ATP and a decrease in the levels of immunosuppressive
adenosine within the tumor microenvironment (TME). A high level of ATP increases pro-inflammatory
cytokine levels and promotes both T-cell proliferation and the stimulation of dendritic
cells (DCs) and other myeloid-derived cells that are necessary for innate and adaptive
immunity. CD39, a cell surface ectonucleosidase, is upregulated on tumor cells as
an immune evasion strategy. Blocking its action may improve anti-tumor immune responses.;
Semantic type(s)