Preferred Label : Technetium Tc-99m Anti-HER2 Affibody HPArk2;
NCIt synonyms : Technetium Tc-99m Anti-HER2 Antagonist HPArk2; 99mTc-HPArk2; 99mTc-labeled HER2 Affibody HPArk2;
NCIt definition : A radioconjugate composed of an affibody targeting human epidermal growth factor receptor
2 (HER2; EGFR2; ErbB2), labeled with technetium Tc 99m, with potential imaging activity
using single photon emission computed tomography (SPECT)/computed tomography (CT).
Upon administration, the anti-HER2 affibody moiety of technetium Tc-99m anti-HER2
affibody HPArk2 targets and binds to HER2-expressing tumor cells. Upon SPECT/CT imaging,
HER2-expressing tumor cells can be detected. HER2, a receptor tyrosine kinase, is
mutated in many tumor cell types and plays a key role in tumor cell proliferation
and tumor vascularization.;
NCI Metathesaurus CUI : CL1412939;
Origin ID : C175589;
UMLS CUI : C5446640;
Semantic type(s)
- concept_is_in_subset
