Preferred Label : Limantrafin;
NCIt synonyms : pan-NOTCH PPI Inhibitor CB-103; pan-NOTCH Protein-Protein Interaction Inhibitor CB-103;
NCIt definition : An orally bioavailable protein-protein interaction (PPI) inhibitor that targets the
assembly of the NOTCH transcription complex, with potential antineoplastic activity.
Upon oral administration, limantrafin targets and inhibits the NOTCH transcriptional
activation complex in the cell nucleus. This inhibits the expression of NOTCH target
genes and prevents NOTCH signaling, which may inhibit the proliferation of tumor cells
mediated by an overly-active Notch pathway. Overactivation of the Notch signaling
pathway, often triggered by activating mutations, has been correlated with increased
cellular proliferation and poor prognosis in certain tumor types.;
UNII : Q5BB91JL0V;
CAS number : 218457-67-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 218457-67-1
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G-SRS /a ;
Molecule name : CB 103; CB-103;
NCI Metathesaurus CUI : CL1413001;
Origin ID : C175580;
UMLS CUI : C5139664;
Semantic type(s)
- concept_is_in_subset
