NCIt definition : A semi-synthetic glycosaminoglycan (GAG) prepared by extracting GAGs from bovine tracheal
cartilage and consisting of mostly chondroitin sulfate, with anti-arthritic activities
in animals including dogs. Upon administration, polysulfated GAG (PSGAG), a proteolytic
enzyme inhibitor, may inhibit various processes that lead to the loss of cartilaginous
mucopolysaccharides. This may include the inhibition of interleukin-1 (IL-1)-mediated
inflammation and degradation of cartilage proteoglycans and collagen. PSGAG may also
stimulate the synthesis of protein, collagen, proteoglycans, and hyaluronic acid,
which may improve joint function.;