Preferred Label : pNGVL4a-CRT-E6E7L2 DNA Vaccine;
NCIt synonyms : pNGVL4aCRTE6E7L2 DNA Vaccine;
NCIt definition : A therapeutic DNA vaccine encoding human calreticulin (CRT) linked to human papillomavirus
(HPV) type 16 E6, E7, and L2 proteins, with potential immunomodulating and antineoplastic
activities. Upon administration via intramuscular injection with electroporation,
the pNGVL4a-CRT-E6E7L2 DNA vaccine expresses HPV16 E6, E7 and L2 proteins, which may
elicit a cytotoxic T-lymphocyte (CTL) response and humoral immune responses against
tumor cells expressing these proteins, resulting in tumor cell lysis and tumor cell
death. In addition, HPV16 L2-specific neutralizing antibody may prevent a broad spectrum
of HPV infections and HPV-associated cancers. The heat shock protein CRT may potentiate
MHC class I presentation to antigen-specific CD8-positive T-cells, enhancing the induction
of cellular immunity and the potency of the vaccine.;
Molecule name : pNGVL4a-CRT-E6E7L2;
NCI Metathesaurus CUI : CL1412894;
Origin ID : C175536;
UMLS CUI : C5446601;
Semantic type(s)
- concept_is_in_subset
- has_target
