Preferred Label : Muscadine Grape Extract;
NCIt synonyms : MGE;
NCIt definition : An extract derived from the Muscadine grape (Vitis rotundifolia), with potential anti-inflammatory,
antioxidant, anti-lipidemic and chemopreventive activities. The muscadine grape extract
(MGE) contains numerous phytochemicals including hydrolyzable tannins and flavonoids,
such as resveratrol, anthocyanin 3,5-diglucosides, quercetin, ellagic acid, myricetin,
and kaempferol glycosides. Upon administration, the active components in the MGE scavenge
free radicals, protect against oxidation of low-density lipoprotein (LDL), and inhibit
cell damage due to reactive oxygen species (ROS). This inhibits oxidative stress and
protects against DNA damage. MGE also inhibits enzymes involved in inflammation, cell
replication and DNA synthesis, and induces the expression of anti-oxidant enzymes.
The active ingredients may also inhibit certain signaling pathways upregulated in
some tumor cell types, eventually leading to apoptosis and a reduction in tumor cell
proliferation. MGE may also boost energy and prevent fatigue.;
NCI Metathesaurus CUI : CL1412905;
Origin ID : C175526;
UMLS CUI : C4535511;
Semantic type(s)
- concept_is_in_subset
