Preferred Label : Eliapixant;
NCIt synonyms : P2X Purinoceptor 3 Antagonist BAY 1817080; P2X3 Receptor Antagonist BAY 1817080; P2X Ligand-gated Ion Channel 3 Receptor Antagonist BAY 1817080; P2RX3 Antagonist BAY 1817080;
NCIt definition : An orally bioavailable antagonist of the purinergic receptor P2X ligand-gated ion
channel 3 (P2RX3), which may potentially be used to suppress pain and chronic cough.
Upon oral administration, eliapixant selectively binds to and inhibits P2RX3 expressed
on sensory nerve fibers. This may inhibit P2RX3-mediated afferent nerve fiber signaling
including respiratory tract afferent nerve fiber signaling, and result in the suppression
of pain and chronic cough. P2RX3 plays an important role in the cough reflex. It is
also a natural mediator of pain and neurogenic inflammation.;
UNII : 9GH7E6347B;
CAS number : 1948229-21-7;
Molecule name : BAY-1817080; BAY 1817080;
NCI Metathesaurus CUI : CL1412303;
Origin ID : C175513;
UMLS CUI : C5706690;
Semantic type(s)
- concept_is_in_subset
