Deupirfenidone

Preferred Label : Deupirfenidone;

NCIt definition : An orally bioavailable and deuterated form of the synthetic antifibrotic agent pirfenidone, with potential anti-inflammatory and anti-fibrotic activities. Upon administration, deupirfenidone inhibits a variety of pro-inflammatory mediators, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a) and transforming growth factor-beta (TGF-b). This may reduce fibrosis, inflammation and infection, and may repair the impaired lymphatic flow, decrease lymphedema and restore lymphatic function. In the lungs, deupirfenidone may abrogate impaired lung function, lymphoedema and pulmonary fibrosis.;

UNII : 1QC36BHI6S;

CAS number : 1093951-85-9;

Molecule name : LYT 100; LYT-100;

NCI Metathesaurus CUI : CL1656955;

Détails

Origin ID

C175509;

UMLS CUI

C5886815;

Currated CISMeF NLP mapping
- deupirfenidone [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pirfenidone (substance) [SNOMED CT concept]
- Product containing pirfenidone (medicinal product) [SNOMED CT concept]
- pirfenidone [MeSH Supplementary Concept]
- pirfenidone [MeSH concept]
- pirfenidone [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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