Preferred Label : Anti-BTN3A Agonistic Monoclonal Antibody ICT01;
NCIt synonyms : Anti-BTN3A Agonist Monoclonal Antibody ICT01;
NCIt definition : A humanized agonistic monoclonal antibody directed against butyrophilin subfamily
3 member A (BTN3A; CD277), with potential immunomodulating and antineoplastic activities.
Upon administration, the anti-BTN3A agonistic monoclonal antibody ICT01 targets and
binds to BTN3A present on epithelial and tumor cells. BTN3A binding may sensitize
tumor cells to gamma 9 delta 2 (Vg9Vd2) T cell killing. The Vg9Vd2 T cells secrete
effector cytokines and exert a cytolytic effect on tumor cells. This may abrogate
BTN3A-mediated tumor immunity and may enhance anti-tumor immune response. BTN3A, a
member of the butyrophilin superfamily of immunomodulators, is upregulated in tumor
cells.;
Molecule name : ICT 01; ICT-01;
NCI Metathesaurus CUI : CL1412871;
Origin ID : C175508;
UMLS CUI : C5446583;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
