NCIt definition : A semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is
unknown, pentosan polysulfate may act as a buffer to control cell permeability by
preventing irritating solutes from reaching cells coated with it. Administered orally,
excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants
from entering bladder cells and the development or progression of interstitial cystitis
(IC), a complication of some chemotherapies. This agent also exhibits anticoagulant
and fibrinolytic properties. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to relieve pain or discomfort associated with chronic inflammation
of the bladder. It is also being evaluated for its protective effects on the gastrointestinal
tract in people undergoing radiation therapy.;