Preferred Label : Foritinib Succinate;
NCIt definition : The succinate salt form of foritinib, an orally bioavailable inhibitor of the receptor
tyrosine kinases anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (ROS1), with
potential antineoplastic activity. Upon oral administration, foritinib targets, binds
to and inhibits the activity of ALK and ROS1, which leads to the disruption of ALK-
and ROS1-mediated signaling and the inhibition of cell growth in ALK- and ROS1-expressing
tumor cells. In addition, foritinib is able to cross the blood brain barrier. ALK
and ROS1, overexpressed or mutated in many tumor cell types, play key roles in tumor
cell proliferation, survival, invasion and metastasis.;
Molecule name : SAF-189s; SAF 189s;
NCI Metathesaurus CUI : CL1412842;
Origin ID : C175475;
UMLS CUI : C5446556;
Semantic type(s)
- concept_is_in_subset
