Preferred Label : Oncolytic HSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011;
NCIt synonyms : Oncolytic HSV-1 Expressing IL-12 and PD-1 Antibody T3011; oHSV-1 Expressing IL-12 and Anti-PD-1 Antibody T3011; Oncolytic HSV-1 Expressing IL-12/Anti-PD-1 Antibody T3011;
NCIt definition : A genetically engineered oncolytic herpes simplex virus type 1 (oHSV-1) expressing
the human immunostimulating cytokine interleukin-12 (IL-12) and an antibody directed
against the negative immunoregulatory human cell receptor programmed cell death protein
1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon intratumoral administration, oHSV-1 expressing IL-12 and anti-PD-1
antibody T3011 infects and replicates in tumor cells causing viral-mediated tumor
cell lysis. The released virus particles, in turn, infect and replicate in neighboring
tumor cells. Tumor antigens released from the lysed tumor cells also activate the
immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte
(CTL) response, thereby killing nearby non-infected tumor cells. In addition, oHSV-1
expressing IL-12 and anti-PD-1 antibody T3011 promotes the secretion of IL-12 and
anti-PD-1 antibody by the tumor cells. IL-12 promotes the activation of natural killer
cells, which induces both the secretion of interferon-gamma and a cytotoxic T-lymphocyte
(CTL) response against the tumor cells. This results in both immune-mediated tumor
cell death and further inhibition of tumor cell proliferation. Anti-PD-1 antibody
targets, binds to and inhibits PD-1 and its downstream signaling pathways. This may
restore immune function through the activation of T-cells and T-cell-mediated immune
responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin
superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively
regulates T-cell activation and effector function when activated by its ligands programmed
cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion
from host immunity.;
Molecule name : T 3011; MVR-T3011; T-3011;
NCI Metathesaurus CUI : CL1412848;
Origin ID : C175473;
UMLS CUI : C5446554;
Semantic type(s)
- concept_is_in_subset
