Preferred Label : TNFalpha/IL-2-encoding Oncolytic Adenovirus TILT-123;
NCIt synonyms : TNFalpha/IL-2-coding Oncolytic Adenovirus TILT-123; Ad5/3-E2F-d24-hTNFa-IRES-hIL2; Oncolytic Adenovirus TILT-123; TNFalpha/IL2-armed Oncolytic Adenovirus TILT-123;
NCIt definition : A genetically-engineered, replication competent, oncolytic serotype 5/3 capsid-modified
adenovirus and encoding for the T-cell immunostimulatory cytokines tumor nerosis factor-alpha
(TNF-alpha) and interleukin-2 (IL-2), with potential oncolytic and immunostimulating
activities. Upon administration of TNFalpha/IL-2-encoding oncolytic adenovirus TILT-123,
the oncolytic adenovirus binds to specific Ad3 receptors that are highly expressed
on certain tumor cells and selectively infect and replicate in tumor cells, and express
TNF-alpha and IL-2. The oncolytic virus itself induces a viral-mediated tumor cell
lysis which may result in the activation of a systemic immune response against tumor-associated
antigens. The expressed proteins may further stimulate the immune system to modify
the immunosuppressive tumor microenvironment (TME) and induce a cytotoxic T-lymphocyte
(CTL) response against the tumor cells. TILT-123 is designed to replicate only in
cells with defects in the p16/Rb/E2F pathway, attributed to a mutation common in many
solid tumors. Replacement of the Ad5 capsid protein knob with a knob domain from serotype
3 causes higher transduction in cancer cells as compared to normal cells.;
Molecule name : TILT 123; TILT-123;
NCI Metathesaurus CUI : CL1412800;
Origin ID : C175454;
UMLS CUI : C5446535;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
