Preferred Label : Vodudeutentan Sodium;
NCIt synonyms : ETBR Blocker ENB 003; Endothelin B Receptor Blocker ENB 003;
NCIt definition : An antagonist of the immune checkpoint endothelin B receptor (ETBR; EDNRB), with potential
immunomodulating and antineoplastic activities. Upon administration, the ETBR blocker
ENB 003 selectively targets and binds to ETBR expressed on tumor cells. This prevents
ETBR-mediated signaling and may abrogate the immunosuppressive tumor microenvironment
(TME), may enhance a T-cell mediated anti-tumor immune response and may inhibit proliferation
of ETBR-expressing tumor cells. ETBR, a G-protein coupled receptor, is overexpressed
in a variety of tumor cell types and plays a key role in tumor cell proliferation,
invasion, epithelial-mesenchymal transition (EMT) and angiogenesis. It also plays
a role in tumor immunosuppression and blocks T-cell trafficking.;
UNII : AAY8R26VDX;
CAS number : 2364572-10-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2364572-10-9
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G-SRS /a ;
Molecule name : ENB 003; ENB-003;
NCI Metathesaurus CUI : CL1412807;
Origin ID : C175447;
UMLS CUI : C5783395;
Semantic type(s)
- concept_is_in_subset
- has_target
