Preferred Label : EGFR Inhibitor TY-9591;
NCIt synonyms : EGFR Tyrosine Kinase Inhibitor TY-9591;
NCIt definition : An orally available inhibitor of epidermal growth factor receptor (EGFR), including
activating mutations, with potential antineoplastic activity. Upon administration,
the EGFR inhibitor TY-9591 binds to and inhibits EGFR activating mutations, including
the resistance mutation T790M, which prevents EGFR mutant-mediated signaling and leads
to cell death in EGFR mutant-expressing tumor cells. EGFR, a receptor tyrosine kinase
mutated in many tumor cell types, plays a key role in tumor cell proliferation and
tumor vascularization.;
Molecule name : TY-9591; TY 9591;
NCI Metathesaurus CUI : CL1412813;
Origin ID : C175445;
UMLS CUI : C5448020;
Semantic type(s)
- concept_is_in_subset
