Preferred Label : Anti-5T4 Antibody-drug Conjugate SYD1875;
NCIt synonyms : Anti-5T4 ADC SYD1875; ADC SYD1875; Antibody-drug Conjugate SYD1875;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody directed against the oncofetal antigen 5T4 and site-specifically
conjugated to a duocarmycin-based linker-drug valine-citrulline-seco-DUocarmycin-hydroxyBenzamide-Azaindole
(vc-seco-DUBA), with potential antineoplastic activity. Upon administration, the antibody
moiety of SYD1875 selectively binds to cells expressing the 5T4 oncofetal antigen.
After internalization and cleavage within the tumor cell by proteases, the free and
activated duocarmycin payload binds to the minor groove of DNA and alkylates adenine
at the N3 position, which eventually leads to tumor cell apoptosis. 5T4, a transmembrane
glycoprotein, is overexpressed by a variety of cancer cell types; its expression is
correlated with increased invasiveness.;
Molecule name : SYD-1875; SYD 1875;
NCI Metathesaurus CUI : CL1412814;
Origin ID : C175444;
UMLS CUI : C5446526;
Semantic type(s)
- concept_is_in_subset
- has_target
