Preferred Label : Attenuated Measles Virus Encoding SCD Transgene TMV-018;
NCIt definition : A recombinant, attenuated oncolytic measles virus (MV) encoding the prodrug converting
enzyme super cytosine deaminase (SCD), that can potentially be used as an antineoplastic
adjuvant and with potential antineoplastic activity. Upon intra-tumoral injection,
TMV-018 preferentially enters and transfects tumor cells, and expresses SCD, an enzyme
that catalyzes the intracellular conversion of the prodrug flucytosine (5-fluorocytosine;
5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). After administration of
5-FC, the tumor can be eradicated upon activation of 5-FU by SCD. In addition, the
oncolytic MV may infect and lyse tumor cells. In turn, the lysed tumor cells release
various tumor-associated antigens (TAAs), which induce an immune response against
the tumor cells. This may further eradicate tumor cells.;
Molecule name : TMV-018; TMV 018;
NCI Metathesaurus CUI : CL1412818;
Origin ID : C175440;
UMLS CUI : C5446522;
Semantic type(s)
- concept_is_in_subset
