Preferred Label : Anti-HLA-G Antibody TTX-080;
NCIt synonyms : HLA-G Antagonist TTX-080;
NCIt definition : An antibody targeting HLA-G histocompatibility antigen, class I, G (human leukocyte
antigen G; HLA-G), with potential immune checkpoint inhibiting, immunomodulating and
antineoplastic activities. Upon administration, the anti-HLA-G antibody TTX-080 targets
and binds to HLA-G, thereby preventing the binding of HLA-G to its inhibitory receptors
on a variety of immune cells, such as natural killer cells (NKs), T- and B-lymphocytes,
and dendritic cells (DCs). This may prevent the HLA-G-mediated immune suppression,
thereby activating both innate and adaptive immune responses. This may activate anti-tumor
immune responses. HLA-G, an immune checkpoint normally expressed at the maternal-fetal
interface, is expressed across multiple tumor types and plays a key role in cancer
immune evasion.;
Molecule name : TTX 080; TTX-080;
NCI Metathesaurus CUI : CL1412700;
Origin ID : C175374;
UMLS CUI : C5446477;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
