Preferred Label : Zedenoleucel;
NCIt synonyms : Allogeneic MultiTAA-specific T-lymphocytes MT-401; Donor-Derived Multi-Tumor-Associated Antigen-specific T Cells; Zelenoleucel; MT-401-OTS;
NCIt definition : An off-the-shelf (OTS) cellular preparation composed of T-lymphocytes specifically
reactive to the four tumor-associated antigens (TAAs) human Wilms tumor protein-1
(WT1), preferentially expressed antigen in melanoma (PRAME), the cancer-testis antigen
NY-ESO-1, and survivin, with potential immunomodulating and antineoplastic activities.
Upon intravenous administration, zedenoleucel recognizes and kills cancer cells expressing
these TAAs. WT1, NY-ESO-1, PRAME, and survivin are expressed on certain tumor cell
types and play key roles in tumor cell proliferation and survival.;
UNII : L4D9X59F34;
Molecule name : MT 401; MT-401;
NCI Metathesaurus CUI : CL1412662;
Origin ID : C175351;
UMLS CUI : C5448015;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
