Preferred Label : Naltrexone Hydrochloride/Bupropion Hydrochloride;
NCIt synonyms : Bupropion Hydrochloride-Naltrexone Hydrochloride; Bupropion Hydrochloride/Naltrexone Hydrochloride; Naltrexone Hydrochloride-Bupropion Hydrochloride;
NCIt definition : A fixed combination of naltrexone hydrochloride, an opioid antagonist, and bupropion
hydrochloride, an aminoketone antidepressant and a weak inhibitor of the neuronal
reuptake of dopamine and norepinephrine, that may be used for appetite regulation,
weight management and weight loss. Upon oral administration of naltrexone hydrochloride/bupropion
hydrochloride, naltrexone binds to and blocks the various opioid receptors in the
central nervous system. Bupropion inhibits neuronal reuptake of dopamine and norepinephrine,
thereby increasing the level of these neurotransmitters. Bupropion may also have a
direct effect on the hypothalamus, the appetite regulatory center. These actions may
block the rewarding aspects of food and reduce appetite and food cravings, and contribute
to weight loss.;
Drug name : Contrave;
NCI Metathesaurus CUI : CL1412648;
Origin ID : C175305;
UMLS CUI : C5446420;
Semantic type(s)
- concept_is_in_subset
