NCIt synonyms : Monoclonal Antibody SCTA01; Anti-SARS-CoV-2 Spike Protein Monoclonal Antibody SCTA01; Anti-SARS-CoV-2 S Protein Monoclonal Antibody SCTA01;
NCIt definition : A neutralizing human monoclonal antibody directed against the spike (S) protein of
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially
be used for passive immunization against Coronavirus disease 2019 (COVID-19). Upon
administration, upanovimab specifically targets and binds to an epitope on the SARS-CoV-2
S protein, thereby blocking viral attachment and entry into human cells and may thereby
neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate
recovery, and may potentially provide temporary protection against infection with
SARS-CoV-2. S protein, usually found on the surface of SARS-CoV-2, plays an essential
role in the infection pathway of the SARS-CoV-2 virus.;