NCIt definition : An immunoglobulin G1 (IgG1) bispecific antibody targeting both epidermal growth factor
receptor (EGFR; HER1; ErbB1) and leucine-rich repeat-containing G-protein coupled
receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, petosemtamab
simultaneously targets and binds to both EGFR and LGR5, thereby inhibiting the activation
of both EGFR- and LGR5-mediated signaling pathways. This results in the inhibition
of tumor cell proliferation. EGFR, a receptor tyrosine kinase (RTK) upregulated and/or
mutated in a variety of tumor cell types, plays an important role in tumor cell proliferation.
LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor
overexpressed on certain cancer cells; it plays a key role in CSC proliferation and
survival.;
Semantic type(s)