Topoisomerase Inhibitor

Preferred Label : Topoisomerase Inhibitor;

NCIt synonyms : DNA Topoisomerase Inhibitors; Topoisomerase Inhibitors;

NCIt definition : Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis.;

Alternative definition : NCI-GLOSS: A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer.;

Codes from synonyms : CDR0000046665;

Details

Origin ID

C1748;

UMLS CUI

C0598317;

Automatic exact mappings (from CISMeF team)
- Topoisomerase inhibitor (disposition) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Product containing topoisomerase inhibitor (product) [SNOMED CT concept]
- Substance with topoisomerase inhibitor mechanism of action (substance) [SNOMED CT concept]
- topoisomerase inhibitors [MeSH Descriptor]
- topoisomerase inhibitors [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing topoisomerase inhibitor (product) [SNOMED CT concept]
- Substance with topoisomerase inhibitor mechanism of action (substance) [SNOMED CT concept]
- topoisomerase inhibitors [MeSH concept]
- topoisomerase inhibitors [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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