Preferred Label : Elinzanetant;
NCIt definition : An orally bioavailable neurokinin/tachykinin 1 receptor (NK1-receptor; NK1R; NK-1R)
and NK3 receptor (NK-3R; NK3R) antagonist, that may be used to treat vasomotor symptoms
in menopausal woman. Upon oral administration, elinzanetant targets, competitively
binds to and blocks the activity of the NK1R and NK3R in the central nervous system
(CNS), thereby inhibiting the binding of the endogenous ligands and neuropeptides
substance P (SP; neurokinin-1; NK1) and neurokinin B (NKB). This inhibits NK1R/NK3R-mediated
signal transduction and may prevent certain menopausal symptoms such as hot flashes.
Neurokinin-mediated signaling may increase during hormone deficiency and may cause
hot flashes.;
UNII : NZW2BOW35N;
InChIKey : DWRIJNIPBUFCQS-DQEYMECFSA-N;
CAS number : 929046-33-3;
Molecule name : NT-814; NT 814; BAY-3427080; BAY 3427080;
NCI Metathesaurus CUI : CL1412272;
Origin ID : C174774;
UMLS CUI : C5420949;
Semantic type(s)
- concept_is_in_subset
