Preferred Label : Efmarodocokin Alfa;
NCIt synonyms : Recombinant Human Interleukin-22 IgG4-Fc Fusion Protein UTTR1147A; IL-22Fc; IL22-Fc;
NCIt definition : A recombinant fusion protein consisting of human cytokine interleukin (IL) 22 (IL-22)
fused to the Fc portion of human immunoglobulin (Ig) G4, with potential cell protective
and immunomodulatory activities. Upon administration of efmarodocokin alfa, IL-22
binds to its cognate receptor IL-22R, which is highly expressed in parenchymal tissues
and epithelial cells at mucosal surfaces. This leads to the activation of IL-22/IL-22R-mediated
signal transduction pathways, and results in the activation of signal transducer and
activator of transcription 3 (STAT3). STAT3 activation may have a protective and regenerative
effect and may protect against the development of various inflammatory and immunological
diseases. IL-22, a member of the IL-10 family of cytokines, is produced by various
immune cells and upregulated during inflammation. It plays a key role in controlling
immune responses and bacterial infection, and in the enhancement of intestinal barrier
function, gut immunity, and tissue repair.;
UNII : NYZ11835VX;
CAS number : 2247840-74-8;
Molecule name : UTTR1147A; RO7021610; RG 7880; RG-7880;
NCI Metathesaurus CUI : CL1412265;
Origin ID : C174771;
UMLS CUI : C5420947;
Semantic type(s)
- concept_is_in_subset
