" /> Artesunate/Pyronaridine - CISMeF





Preferred Label : Artesunate/Pyronaridine;

NCIt synonyms : Artesunate-Pyronaridine; Pyronaridine-Artesunate; Pyronaridine/Artesunate;

NCIt definition : A fixed dose artemisinin-based combination therapy (ACT) consisting of artesunate, a semi-synthetic derivative of the sesquiterpine lactone, and pyronaridine, a benzonaphthyridine derivative, with anti-malarial and potential antiviral activities. Upon oral administration of artesunate/pyronaridine and hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells (RBCs), reactive oxygen species and carbon-centered radicals form, which damage and kill parasitic organisms. Pyronaridine inhibits the formation of beta-hematin, which results in the accumulation of toxic heme within the parasite. In addition, pyronaridine inhibits glutathione-dependent degradation of hematin. This promotes hematin-induced lysis of RBCs, resulting in parasite death. Artesunate/pyronaridine may also exhibit antiviral activity against some viruses by modulating the type-1 interferon (IFN) pathway.;

Drug name : Pyramax;

NCI Metathesaurus CUI : CL1411822;

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Keyword's position in hierarchy(ies) : arborescence

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21/05/2024


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