Preferred Label : Fluorescent Imaging Agent cRGD-ZW800-1;
NCIt synonyms : cyclo-(RGDyK)-ZW800-1;
NCIt definition : An imaging agent composed of the cyclic arginine-glycine-aspartic acid (cRGD)-based
peptide derivative cyclo-(RGDyK) conjugated to the near-infrared (NIR) fluorophore
ZW800-1, with potential use as a tumor-selective fluorescent imaging agent. Upon administration
of the fluorescent imaging agent cRGD-ZW800-1, the cRGD moiety selectively binds to
integrins, including alphaVbeta3, alphaVbeta5 and alphaVbeta6, expressed on tumor
cells and tumor-associated vascular endothelium. Upon intraoperative fluorescence
imaging, tumor cells and tumor-associated vascular endothelium expressing these integrins
can be visualized. Integrins are transmembrane glycoproteins upregulated on proliferating
tumor vessel endothelial cells and various cancer cells; their overexpression has
been associated with neovascularization, differentiation, proliferation of tumor cells,
metastasis and an overall poor prognosis.;
Molecule name : cRGD-ZW800-1;
NCI Metathesaurus CUI : CL1411839;
Origin ID : C174523;
UMLS CUI : C5418104;
Semantic type(s)
- concept_is_in_subset
