Preferred Label : Gallium Ga 68-NOTA-MAL-Cys39-exendin-4;
NCIt synonyms : 68Ga-NOTA-MAL-Cys39-exendin-4;
NCIt definition : A radiopharmaceutical tracer composed of the glucagon-like peptide-1 receptor (GLP-1R)
agonist exendin-4 in which the serine residues (ser39) are replaced with cysteine
(cys39) linked by the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA), which is linked to maleimide (MAL), to the positron-emitting radionuclide
gallium Ga 68, with potential use in diagnostic imaging upon positron emission tomography
(PET)/computed tomography (CT). Upon administration of gallium Ga 68-NOTA-MAL-Cys39-exendin-4,
the exendin-4 moiety binds to GLP-1R. The radionuclide moiety can be detected using
PET/CT and GLP-1R-expressing tumors can be localized and visualized. GLP-1R, which
is located on beta cells and regulates insulin secretion, is overexpressed on insulinomas,
which are insulin-secreting neuroendocrine tumors (NETs).;
NCI Metathesaurus CUI : CL1411833;
Origin ID : C174521;
UMLS CUI : C5420828;
Semantic type(s)
- concept_is_in_subset
