Preferred Label : Maackia amurensis Seed Lectin;
NCIt synonyms : MASL;
NCIt definition : A preparation of lectin extracted from the seeds of Maackia amurensis, with potential
antineoplastic activity. Upon administration, Maackia amurensis seed lectin (MASL)
may target and bind to podoplanin (PDPN), thereby blocking the activation of PDPN
by endogenous ligands. This may inhibit tumor cell growth, migration and metastasis
that result from PDPN activation. PDPN, a transmembrane receptor glycoprotein that
is overexpressed in some cancer types, promotes tumor cell migration, invasion, and
metastasis upon activation by various endogenous ligands.;
NCI Metathesaurus CUI : CL1412017;
Origin ID : C174518;
UMLS CUI : C5417747;
Semantic type(s)
- concept_is_in_subset
- has_target
