Preferred Label : Tag-7 Gene-modified Vaccine;
NCIt synonyms : GMV; Tag-7 GMV; Tag-7 Gene-modified Inactivated Tumor Cell Vaccine; Tag7 Gene-modified Inactivated Tumor Cell Vaccine;
NCIt definition : A cell-based vaccine composed of autologus inactivated tumor cells that have been
genetically modified with the gene encoding for the innate immunity protein peptidoglycan
recognition protein 1 (Tag7; PGRP-S; PGLYRP1; TAG-7), with potential immunomodulating
and antineoplastic activities. Upon subcutaneous administration of Tag-7 gene-modified
vaccine (GMV), the Tag-7 transfected tumor cells express Tag-7 which is presented
to the immune system and activates the innate immune system. This may activate the
immune system to exert a T-lymphocyte-mediated immune response against Tag-7-expressing
tumor cells.;
NCI Metathesaurus CUI : CL1412012;
Origin ID : C174513;
UMLS CUI : C5417746;
Semantic type(s)
- concept_is_in_subset
