Preferred Label : Lutetium Lu 177-DTPA-omburtamab;
NCIt synonyms : 177Lu-DTPA-omburtamab;
NCIt definition : A radioimmunoconjugate consisting of omburtamab, a murine immunoglobulin G1 (IgG1)
antibody directed against the surface immunomodulatory glycoprotein human B7-homolog
3 (B7-H3, CD276), conjugated, via the chelating agent diethylenetriaminepentaacetic
acid (DTPA), to the radioisotope lutetium Lu 177, with potential antineoplastic activity.
Upon intracerebroventricular administration of lutetium Lu 177-DTPA-omburtamab, the
omburtamab moiety binds to B7-H3 expressed on certain tumor cells. Upon binding, lutetium
Lu 177-DTPA-omburtamab delivers a cytotoxic dose of beta radiation to B7-H3-expressing
cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory
protein superfamily, is overexpressed on certain tumor cell types and on various immune
cells but is minimally expressed by normal human tissues. B7-H3 is a negative regulator
of T-cell activation; its overexpression plays a key role in immuno-evasion, tumor
cell invasion and metastasis, and is correlated with poor prognosis.;
NCI Metathesaurus CUI : CL1411985;
Origin ID : C174423;
UMLS CUI : C5420770;
Semantic type(s)
- concept_is_in_subset
- has_target
