Preferred Label : BCMA CART Cells Secreting Mutant PD-1Fc Fusion Protein;
NCIt synonyms : BCMA-PD1-CART Cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation
antigen (BCMA; TNFRSF17) and secrete a fusion protein composed of programmed death
1 (PD-1; PDCD1; CD279; programmed cell death-1) and a human immunoglobulin Fc region,
with potential immunomodulating and antineoplastic activities. Upon administration
of the BCMA CART cells secreting mutant PD-1Fc fusion protein, these T-cells target
and bind to tumor cells expressing BCMA and induce selective cytotoxicity in those
tumor cells. The expressed PD-1-Fc fusion protein targets and binds to programmed
death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1
ligand 1) expressed on tumor cells, thereby halting PD-1/PD-L1-mediated signaling.
This may decrease T-cell exhaustion and may enhance T-cell activity against the PD-L1-expressing
tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and
B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor
superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed
on malignant plasma cells and plays a key role in plasma cell proliferation and survival.
PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor
immune evasion by binding to its ligand PD-L1 expressed on tumor cells.;
NCI Metathesaurus CUI : CL1411934;
Origin ID : C174413;
UMLS CUI : C5420765;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
