Preferred Label : Casdozokitug;
NCIt synonyms : Anti-IL-27 Blocking Antibody SRF388; Anti-IL-27p28 Monoclonal Antibody SRF388;
NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody against the p28 subunit of the
immunosuppressive cytokine interleukin-27 (IL-27p28), with potential immune-activating,
pro-inflammatory and antineoplastic activities. Upon administration, casdozokitug
targets and binds to IL-27p28, and inhibits the interaction of IL-27 with the IL-27
receptor subunit alpha (IL-27RA). This prevents the activation of IL-27RA and prevents
IL-27-mediated signaling. This reduces signal transducer and activator of transcription
1 (STAT1) phosphorylation which leads to increased secretion of pro-inflammatory cytokines,
such as interferon-gamma (IFN-g) and tumor necrosis factor-alpha (TNF-a). It also
decreases the expression of inhibitory immune checkpoint receptors, such as programmed
death-ligand 1 (PD-L1), T cell immunoreceptor with Ig and ITIM domains (TIGIT) and
lymphocyte-activation gene 3 (LAG3), on immune cells. This may enhance a T-cell mediated
immune response against tumor cells that rely on IL-27 for immune escape. IL-27, a
heterodimeric member of the IL-12/IL-23 cytokine family composed of IL-27p28 and Epstein-Barr
virus induced gene 3 (EBI3), plays an important role in the immunosuppressive tumor
microenvironment (TME). IL-27 signals through the JAK-STAT pathway to limit the duration
and intensity of a T cell-mediated immune response during infection and cancer by
altering immunoregulatory receptor expression and proinflammatory cytokine secretion.;
UNII : AL6I5N2HTN;
CAS number : 2643331-37-5;
Molecule name : SRF 388; SRF-388; CHS-388; CHS 388;
NCI Metathesaurus CUI : CL1411935;
Origin ID : C174410;
UMLS CUI : C5783007;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
