Preferred Label : Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4 T-cells CTL
19;
NCIt definition : A preparation of allogeneic, third-party, CD4 T-lymphocytes that specifically recognizes
the human leukocyte antigen (HLA)-DPB1*0401 and transduced with a suicide gene, with
potential antineoplastic activity. Upon administration, allogeneic third-party suicide
gene-transduced anti-HLA-DPB1*0401 CD4 T-cells CTL 19 specifically target and kill
HLA-DPB1*0401-positive leukemic cells. The suicide gene causes the destruction of
the T-cell clone upon the administration and presence of ganciclovir, which enhances
the safety of the agent. HLA-DP is expressed by many leukemic cells.;
Molecule name : CTL 19; CTL-19;
NCI Metathesaurus CUI : CL1411953;
Origin ID : C174401;
UMLS CUI : C5418086;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
