Preferred Label : Misitatug Blivedotin;
NCIt synonyms : Anti-mesothelin Antibody-drug Conjugate RC88; ADC RC88; Anti-mesothelin/MMAE ADC RC88; Anti-mesothelin/MMAE Antibody-drug Conjugate RC88;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody directed against the human
cell surface glycoprotein mesothelin and conjugated, via a cleavable linker, to the
microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential
antineoplastic activity. Upon administration of misitatug blivedotin, the antibody
moiety targets and binds to the tumor associated antigen (TAA) mesothelin on the surface
of tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds
to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell
cycle arrest and apoptosis in mesothelin-expressing tumor cells. Mesothelin is overexpressed
by all mesotheliomas and a variety of other cancers, while it is minimally expressed
in normal tissue.;
UNII : NS5GTS5FLQ;
CAS number : 2767203-06-3;
Molecule name : RC-88; RC 88;
NCI Metathesaurus CUI : CL1411951;
Origin ID : C174395;
UMLS CUI : C5418082;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
