Preferred Label : Anti-mesothelin/MMAE Antibody-drug Conjugate RC88;
NCIt synonyms : Anti-mesothelin Antibody-drug Conjugate RC88; ADC RC88; Anti-mesothelin/MMAE ADC RC88;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody directed against the human
cell surface glycoprotein mesothelin and conjugated, via a cleavable linker, to the
microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential
antineoplastic activity. Upon administration, the antibody moiety of anti-mesothelin/MMAE
ADC RC88 targets and binds to the tumor associated antigen (TAA) mesothelin on the
surface of tumor cells. Upon internalization and the release of MMAE, MMAE targets
and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M
phase cell cycle arrest and apoptosis in mesothelin-expressing tumor cells. Mesothelin
is overexpressed by all mesotheliomas and a variety of other cancers, while it is
minimally expressed in normal tissue.;
Molecule name : RC-88; RC 88;
NCI Metathesaurus CUI : CL1411951;
Origin ID : C174395;
UMLS CUI : C5418082;
Semantic type(s)
- concept_is_in_subset
