Preferred Label : Gallium Ga 68-NOTA-hGZP;
NCIt synonyms : [68Ga]-NOTA-hGZP; 68Ga-NOTA-hGZP;
NCIt definition : A radiotracer composed of hGZP, a biotinylated human granzyme B peptide, conjugated
with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential imaging
activity using positron emission tomography (PET). Upon administration, the hGZP moiety
of gallium Ga 68-NOTA-hGZP targets and binds to granzyme B, a cytotoxic serine protease
released by cytotoxic T-lymphocytes (CTLs), in tumors. Upon PET imaging, tumoral granzyme
B expression can be visualized, and CTL activation and activity can be assessed.;
NCI Metathesaurus CUI : CL1411960;
Origin ID : C174392;
UMLS CUI : C5420754;
Semantic type(s)
- concept_is_in_subset
