Preferred Label : Gallium Ga 68-NOTA-anti-MMR-VHH2 Nanobody;
NCIt synonyms : 68Ga-NOTA-MMR-VHH2 Nanobody; 68Ga-NOTA-anti-MMR-VHH2;
NCIt definition : A radiotracer composed of a nanobody against the macrophage mannose receptor (MMR,
CD206) conjugated with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential imaging
activity using positron emission tomography (PET). Upon administration, the nanobody
moiety of gallium Ga 68-NOTA-anti-MMR-VHH2 nanobody binds to MMR on tumor-associated
macrophages (TAMs). Upon PET imaging, MMR-expressing TAMs can be visualized. MMR-expressing
TAMs play a role in tumor growth and metastasis as well as immunotherapy resistance.;
NCI Metathesaurus CUI : CL1411957;
Origin ID : C174389;
UMLS CUI : C5420753;
Semantic type(s)
- concept_is_in_subset
