NCIt definition : A peptide antagonist of the transcription factor CCAAT/enhancer-binding protein beta
(C/EBP beta), with potential antineoplastic activity. Upon administration, lucicebtide
targets and inhibits the activity of C/EBP beta. This prevents the expression of C/EBP
beta target genes and proteins, including the anti-apoptotic protein B-cell lymphoma
2 (Bcl-2), cyclins and inhibitor of differentiation (ID) family of proteins, which
are involved in cell proliferation, differentiation, and cell cycle regulation. This
may lead to apoptosis in tumor cells. C/EBP beta is overexpressed in many cancers
and plays an important role in the regulation of cell differentiation; its expression
is associated with tumor cell survival and proliferation.;
UNII : CT77XS2YLT;
CAS number : 2407100-74-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2407100-74-5
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G-SRS /a ;
Semantic type(s)