Preferred Label : Olitigaltin;
NCIt synonyms : Gal-3 Inhibitor GB0139; Galectin-3 Inhibitor GB-0139;
NCIt definition : An inhaled, small molecule inhibitor of galectin-3 (Gal-3), with potential anti-fibrotic
activity. Upon administration, olitigaltin inhibits the activity of Gal-3. This may
prevent the activation of alveolar macrophages and fibroblasts, and the resulting
fibrosis in the lungs. Gal-3, a beta-galactoside-binding lectin, is expressed in multiple
cell types including macrophages, fibroblasts, activated T-lymphocytes and epithelial
cells. It is upregulated in fibrotic lung diseases including idiopathic pulmonary
fibrosis (IPF) and interstitial pneumonia associated with collagen vascular disease
(CVD-IP), and plays an important role in fibrosis in multiple organs. It is also often
dysregulated in cancers, and may play a role in angiogenesis, cell proliferation and
cell survival.;
UNII : 60Y0GUO72B;
InChIKey : YGIDGBAHDZEYMT-MQFIMZJJSA-N;
CAS number : 1450824-22-2;
Molecule name : GB-0139; GB 0139; TD-139; TD 139;
NCI Metathesaurus CUI : CL1407786;
Origin ID : C174126;
UMLS CUI : C5667209;
Currated CISMeF NLP mapping
- GB-0139 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- GB-0139 [MeSH Supplementary Concept]
- concept_is_in_subset
