Preferred Label : Anti-CD38 Antibody-drug Conjugate STI-6129;
NCIt synonyms : Anti-CD38-Duostatin 5.2 ADC STI-6129; Anti-CD38 ADC STI-6129; ADC STI-6129;
NCIt definition : An antibody-drug conjugate (ADC) composed of STI-5171, a fully human monoclonal antibody
targeting human cell surface glycoprotein and tumor-associated antigen (TAA) CD38,
site-specifically conjugated, via a non-polyethylene glycol linker, to a monomethyl
auristatin F (MMAF)-derived cytotoxic payload, with potential antineoplastic activity.
Upon administration of anti-CD38 ADC STI-6129, the antibody moiety targets and binds
to CD38 on tumor cells. Upon antibody/antigen binding and internalization, the MMAF
derivative binds to and inhibits tubulin polymerization, which results in G2/M phase
arrest and tumor cell apoptosis. CD38, a type II transmembrane glycoprotein, is present
on various immune cells and hematologic malignancies; its expression has been correlated
with poor prognosis.;
Molecule name : STI 6129; STI-6129; CD38-077; LNDS1001;
NCI Metathesaurus CUI : CL1407961;
Origin ID : C174057;
UMLS CUI : C5418063;
Semantic type(s)
- concept_is_in_subset
- has_target
