Preferred Label : Divarasib;
NCIt synonyms : KRAS G12C Inhibitor GDC-6036;
NCIt definition : An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with
potential antineoplastic activity. Upon oral administration, divarasib selectively
targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS,
a member of the RAS family of oncogenes, serves an important role in cell signaling,
division and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell growth, proliferation, invasion, and metastasis.;
UNII : E6S21PVT91;
CAS number : 2417917-17-8;
Molecule name : GDC 6036; GDC-6036; RG 6330; RG-6330;
NCI Metathesaurus CUI : CL1407880;
Codes from synonyms : 122139;
Origin ID : C173995;
UMLS CUI : C5706685;
Semantic type(s)
- concept_is_in_subset
- has_target
