Preferred Label : Anti-HER2 Antibody-drug Conjugate BAT8001;
NCIt synonyms : ADC BAT8001; Anti-HER2 ADC BAT8001;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2) conjugated via an uncleavable linker to an as of yet undisclosed maytansine
derivative, with potential antineoplastic activity. Upon administration of the anti-HER2
ADC BAT8001, the anti-HER2 monoclonal antibody targets and binds to HER2 expressed
on tumor cells. Upon cellular uptake, the cytotoxic maytansine derivative binds to
tubulin, thereby affecting microtubule assembly and disassembly dynamics. This inhibits
tumor cell proliferation and induces apoptosis in HER2-expressing tumor cells. HER2,
a tyrosine kinase receptor, is overexpressed by many cancer cell types.;
Molecule name : BAT-8001; BAT 8001;
NCI Metathesaurus CUI : CL1407842;
Origin ID : C173966;
UMLS CUI : C5418043;
Semantic type(s)
- concept_is_in_subset
