Preferred Label : Anti-HER2 Antibody-drug Conjugate DP303c;
NCIt synonyms : Antibody-drug Conjugate DP303c; ADC DP303c;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting human
epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) and conjugated to an as of
yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration
of anti-HER2 ADC DP303c, the antibody moiety targets and binds to HER2 on tumor cells.
Upon antibody/antigen binding and internalization, the cytotoxic agent induces tumor
cell apoptosis, through an as of yet not publicly known mechanism. HER2, a tyrosine
kinase receptor, is overexpressed by many cancer cell types.;
Molecule name : DP-303c; DP 303c;
NCI Metathesaurus CUI : CL1407846;
Origin ID : C173962;
UMLS CUI : C5418040;
Semantic type(s)
- concept_is_in_subset
