Preferred Label : CD20-CD19 Compound CAR T Cells;
NCIt synonyms : CD20-CD19 cCAR-T Cells; CD19/CD20-expressing Compound CAR-T Cells; CD20-CD19 cCAR T Cells;
NCIt definition : A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound
chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific
for the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20) and one
specific for the TAA CD19, with potential immunomodulating and antineoplastic activities.
Upon administration, the CD20-CD19 cCAR T cells specifically and simultaneously target
and bind to tumor cells expressing CD20 and/or CD19. This induces selective toxicity
in tumor cells that express CD20 and/or CD19. Both CD19 and CD20 are B-cell-specific
cell surface antigens overexpressed in B-cell lineage malignancies. Targeting two
different antigens may improve coverage and protect against antigen escape and relapse
as it is less likely for tumor cells to lose both antigens.;
NCI Metathesaurus CUI : CL1407867;
Origin ID : C173960;
UMLS CUI : C5420485;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
