Preferred Label : Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein;
NCIt synonyms : MV-s-NAP; MV Encoding NAP; Oncolytic Measles Virus Encoding H. pylori NAP;
NCIt definition : An attenuated oncolytic Edmonston (Ed) strain of measles virus (MV) encoding the N-terminus
of the human lambda immunoglobulin light chain containing the Helicobacter pylori
neutrophil-activating protein (NAP), with potential immunostimulating and antineoplastic
activities. Upon administration, the oncolytic measles virus encoding H. pylori NAP
selectively infects and replicates in tumor cells, leading to syncytia formation and
tumor cell lysis. The expressed NAP, a toll-like receptor-2 (TLR2) agonist, may stimulate
the secretion of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-a),
interleukin (IL)-1 and IL-6, leading to local inflammatory reaction in the tumor microenvironment
(TME). H. pylori NAP, a bacterial antigen and potent immunomodulator, may enhance
the antitumor effect of oncolytic MV.;
NCI Metathesaurus CUI : CL1407687;
Origin ID : C173889;
UMLS CUI : C5420431;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
