Atazanavir/Ritonavir

Preferred Label : Atazanavir/Ritonavir;

NCIt synonyms : Ritonavir/Atazanavir; Atazanavir-Ritonavir;

NCIt definition : A fixed combination of atazanavir, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, and ritonavir, a cytochrome P450 3A4 (CYP3A4) inhibitor, that may be used to treat HIV-1 infection. Upon oral administration of atazanavir/ritonavir, atazanavir selectively binds to the active site of HIV-1 protease and inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions. Ritonavir inhibits CYP3A4, thereby limiting the metabolism of atazanavir, which is a CYP3A4 substrate, and increasing its systemic exposure. This leads to an increased concentration and half-life of atazanavir as compared to the administration of atazanavir without ritonavir.;

Drug name : Anzavir-R;

Details

Origin ID

C173857;

UMLS CUI

C1977391;

Automatic exact mappings (from CISMeF team)
- Atazanavir and Ritonavir [ICD-11 Extension code]
- atazanavir, ritonavir drug combination [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Atazanavir+Ritonavir [LOINC component]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Atazanavir+Ritonavir [LOINC component]
- atazanavir and ritonavir [ATC Code]
- atazanavir, ritonavir drug combination [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- atazanavir and ritonavir [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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