Preferred Label : Recombinant Spike-protein Receptor-binding Domain-dimer SARS-CoV-2 Vaccine;
NCIt synonyms : Recombinant Spike-protein RBD-dimer Coronavirus Vaccine; Recombinant S-protein RBD-dimer SARS-CoV-2 Vaccine;
NCIt definition : A recombinant protein-based vaccine composed of a recombinant spike (S) protein receptor-binding
domain (RBD)-dimer, produced in Chinese hamster ovary (CHO) cells, of severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), with potential immunomodulating and
anti-coronavirus disease 2019 (COVID-19) activities. Upon intramuscular administration
of the recombinant S-protein RBD-dimer SARS-CoV-2 vaccine, the S protein RBD-dimer
activates the immune system to create anti-SARS-CoV-2 S protein antibodies. The antibodies
recognize and neutralize the S protein and kill SARS-CoV-2. This prevents SARS-CoV-2
infection. S-protein, usually found on the surface of SARS-CoV-2, plays an essential
role in the infection pathway of the SARS-CoV-2 virus. The dimeric form of SARS-CoV-2
RBD may increase its immunogenicity.;
NCI Metathesaurus CUI : CL1407646;
Origin ID : C173850;
UMLS CUI : C5420411;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
