Preferred Label : COVID-19 Vaccine Gam-COVID-Vac Lyo;
NCIt synonyms : Lyophilized rAd26/rAd5-expressing SARS-CoV-2 SP Vaccine Gam-COVID-Vac Lyo; Gam-COVID-Vac Lyo;
NCIt definition : A lyophilized formulation of a recombinant human adenoviral (rAd)-based vaccine encoding
for the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein
(SP), with potential immunomodulating and anti-COVID-19 activities. Gam-COVID-Vac
contains two components: a rAd type 26 (rAd26) prime component encoding the SARS-CoV-2
S protein gene and a rAd type 5 (rAd5) boost component encoding the SARS-CoV-2 S protein
gene Upon intramuscular administration of the Gam-COVID-Vac Lyo, the Ad infects cell
and produces SP. The released SP activates the immune system to induce a humoral and
cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2 infection
and inhibit viral replication. SP, usually found on the surface of SARS-CoV-2, plays
an essential role in the infection pathway of the SARS-CoV-2 virus.;
NCI Metathesaurus CUI : CL1407552;
Origin ID : C173730;
UMLS CUI : C5400623;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
