Preferred Label : Anti-GPC3-CAR T-lymphocytes TAK-102;
NCIt synonyms : Glypican-3-specific CAR T Cells TAK-102; Anti-CEA IgCD28TCR-Transduced Autologous T Cells; CAR T Cells TAK-102; Anti-GPC3 CAR T Cells TAK-102;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-GPC3-CAR T-lymphocytes TAK-102
specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor
cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family,
is overexpressed on certain tumor cell types while minimally expressed on normal,
healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.;
Molecule name : TAK-102; TAK 102;
NCI Metathesaurus CUI : CL1407565;
Origin ID : C173713;
UMLS CUI : C5418021;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
