Preferred Label : Engineered Toxin Body Targeting CD38 TAK-169;
NCIt synonyms : CD38-targeted ETB TAK-169; ETB Targeting CD38 TAK-169;
NCIt definition : An engineered toxin body (ETB) containing a single chain variable fragment (scFv)
from an antibody targeting the cell surface glycoprotein ADP-ribosyl cyclase 1 (CD38)
that is fused to a cytotoxic payload composed of the enzymatically active, de-immunized,
ribosome-inactivating cytotoxic payload Shiga-like toxin-A subunit (SLTA), with potential
antineoplastic activity. Upon administration, the anti-CD38 scFv moiety of TAK-169
specifically targets and binds to CD38-expressing tumor cells. Upon internalization,
the SLTA moiety is released and acts as an N-glycosidase, which binds to and removes
an adenine nucleobase from the 28S RNA component of the 60S ribosomal subunit.of ribosomes
This prevents ribosome activity, This inhibits protein synthesis and leads to apoptosis
in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present
on various immune cells and hematologic malignancies; its expression has been correlated
with poor prognosis.;
Molecule name : TAK-169; TAK 169;
NCI Metathesaurus CUI : CL1407530;
Origin ID : C173707;
UMLS CUI : C5418019;
Semantic type(s)
- concept_is_in_subset
- has_target
